Effect of membrane vesicles produced under different pH conditions on the ability of <i>Enterococcus faecalis</i> to tolerate stressful environments and macrophages' inflammatory response.

ABSTRACT: Enterococcus faecalis is frequently identified in persistent apical periodontitis lesions and possesses the ability to survive within the alkaline environment of the root canal system after treatment. Previously, we found that the secretion of pro-inflammatory cytokines by macrophages is stimulated by membrane vesicles (MVs) produced by E. faecalis at pH levels of 7.0 and 9.0. However, the influence of MVs on the survival of E. faecalis under stress conditions and the regulatory impact on macrophage-mediated inflammation require further elucidation. The present study demonstrated that the incorporation of pH 7.0 and 9.0 E. faecalis MVs enhances the bacterium's tolerance to alkaline conditions, hyperosmolarity, oligotrophic environments, and chlorhexidine glucona

SUBMITTER: Chan P 

PROVIDER: S-EPMC12632260 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature