<i>Staphylococcus aureus</i> encodes four differentially regulated pyruvate transporters.

ABSTRACT: The success of Staphylococcus aureus as a pathogen is attributable, in part, to its ability to exploit the diverse nutrient sources available during infection. Critical to this success are the pathways involving pyruvate that serve as a nexus for energy production, oxidative metabolism, and biosynthetic processes. When available, bacteria acquire pyruvate from the environment to fuel growth. Recently, LrgAB was identified as a pyruvate transporter under microaerobic conditions, leading us to speculate that S. aureus encodes other pyruvate transporters that are active during aerobic growth. In this study, we used the toxic pyruvate analog, 3-fluoropyruvic acid (3-FP), to isolate mutants with impaired pyruvate uptake. Whole-genome sequencing (WGS) of these mutants revealed muta

SUBMITTER: Endres JL 

PROVIDER: S-EPMC12632267 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature