<i>Pseudomonas aeruginosa</i> differentially influences antibiotic-resistant <i>Staphylococcus aureus</i> emergence and expansion in hyperglycemic environments.

ABSTRACT: Individuals with poorly controlled diabetes mellitus often develop multispecies skin and soft tissue infections, with Staphylococcus aureus and Pseudomonas aeruginosa among the most prevalent bacteria isolated from infection sites worldwide. Diabetic infections are recalcitrant to conventional antibiotic regimens and may be a reservoir for emergent antibiotic-resistant bacterial strains. Supporting this, we have previously shown that rifampicin treatment elicits the emergence and expansion of rifampicin-resistant (Rif-r) S. aureus only in diabetic mice, potentially due to greater bacterial outgrowth increasing the frequency of resistance-conferring mutations. However, whether S. aureus exhibits altered resistance outcomes during multispecies diabetic infections

SUBMITTER: Darwitz BP 

PROVIDER: S-EPMC12632273 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature