Chronic alcohol intake elicits distinct multi-omic profiles in the liver <i>versus</i> skeletal muscle of mice.

ABSTRACT: Alcohol-related liver disease and alcohol-related myopathy are widespread consequences of chronic alcohol use. However, understanding of the associated molecular mechanisms and effective treatments remains limited. To address this, we employed multi-omics to uncover molecular blueprints of liver versus skeletal muscle responses to chronic alcohol exposure, using a pre-clinical mouse model showing signs of alcohol-related liver dysregulation (diminished liver phosphatidylcholine-to-phosphatidylethanolamine lipid ratio) and alcohol-related myopathy (reduced muscle mass and strength). We found that the liver was more sensitive to chronic alcohol than muscle across the transcriptome, proteome and metabolome levels, but both tissues were equally sensitive at the lipidome level. The liver

SUBMITTER: Willis CRG 

PROVIDER: S-EPMC12632299 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature