Roles of G-protein coupled receptors and mechanosensitive ion channels in pressure-induced chronotropy of lymphatic vessels.

ABSTRACT: Active lymph pumping relies on the spontaneous contractions of collecting lymphatic vessels, with frequencies that are exquisitely sensitive to changes in intraluminal pressure. This homeostatic and mechanosensitive mechanism, termed pressure-induced lymphatic chronotropy, enables lymph transport to be matched to the filling state of the lymphatic capillaries. We investigated the mechanistic basis of pressure-induced chronotropy using ex vivo contraction assays of mouse popliteal collecting vessels, in which contraction frequency increased >10-fold with a 5 cmH₂O pressure change. The contractile, electrophysiological and transcriptional similarities between lymphatic muscle and arterial smooth muscle led us to hypothesize that pressure-dependent chronotropy shares a parallel sig

SUBMITTER: Davis MJ 

PROVIDER: S-EPMC12632312 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature