PPARG directs trophoblast cell fate and establishment of the uterine-placental interface.

ABSTRACT: The expansion and differentiation of trophoblast stem (TS) cells are critical for defining fundamental properties of the placenta. Specialized trophoblast cells exit the placenta and enter and transform the uterus, including restructuring uterine spiral arteries. In the human these cells are referred to as extravillous trophoblast (EVT) cells, whereas in the rat they are termed invasive trophoblast cells. Mechanisms governing invasive trophoblast cell differentiation remain poorly understood. We investigated peroxisome proliferator-activated receptor gamma (PPARG) as a potential regulator of EVT/invasive trophoblast cell development. In first trimester human placentas, PPARG transcripts and protein were detected in the EVT cell column and increased in amount as human T

SUBMITTER: Dominguez EM 

PROVIDER: S-EPMC12632317 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature