The Impact of Serum on a Complex Synthetic Community Model of the Subgingival Microbiome.

ABSTRACT: Despite rapid advances in characterizing the human microbiome, the ecological pressures shaping its transitions from healthy to diseased states remain poorly resolved. This is particularly true for periodontitis, a slow-progressing chronic inflammatory disease associated with well-defined shifts in the subgingival microbiome. Here, we report the development of a complex synthetic community model of the subgingival microbiome, designed for systematic interrogation of ecological factors that drive community restructuring. The model includes 22 prevalent and abundant subgingival species maintained in mucin-rich medium under microaerophilic, continuous culture conditions, in a chemostat. Using this system, we interrogated the impact of serum, as a surrogate for the inflammatory exudate, on com

SUBMITTER: Li L 

PROVIDER: S-EPMC12632320 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature