Transposon Regulation in the <i>Caenorhabditis elegans</i> Germline and Soma.

ABSTRACT: Transposons are parasitic nucleic acids present in most genomes. The ability of transposons to mobilize makes them a source of genetic diversity and a threat to genome integrity. Interestingly, mutations in the C. elegans gene mut-2/rde-3 increases the rate of transposition in the germline, but not in the soma, suggesting that the C. elegans germline and soma employ different strategies to regulate Tc1 transposition. Here, we develop fluorescence reporters for studying DNA transposon regulation in living C. elegans in a tissue-specific manner and we use candidate gene testing and genetic screening approaches to identify factors that regulate Tc1 mobility in the germline and/or the soma of the animal. We find that both cytoplasmic and nuclear compon

SUBMITTER: Chang C 

PROVIDER: S-EPMC12632400 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature