Lung-Derived Small Extracellular Vesicles Containing miR-15a-5p/miR-96-5p Promote Myocardial Fibrosis in Hypertrophic Cardiomyopathy via Targeting SMAD7.

ABSTRACT: Small extracellular vesicles (sEVs) are membrane-bound nanoparticles released by cells for intercellular or inter-tissue communication and play key roles in multiple cardiovascular disorders. However, the mechanisms underlying sEV-mediated myocardial fibrosis in hypertrophic cardiomyopathy (HCM) are not well understood. In this study, it is discovered that the levels of miR-15a-5p and miR-96-5p in circulating sEVs (^sEVmiR-15a-5p/96-5p) are elevated in HCM patients with myocardial fibrosis. These sEVs enhance fibroblast proliferation and differentiation in vitro. Similar findings are observed in isopropanol (ISO)-induced myocardial fibrosis mouse model, where ^sEVmiR-15a-5p/96-5p levels are elevated, predominantly originating from lung-derived sEVs. GW4869-mediated sEV

SUBMITTER: Long M 

PROVIDER: S-EPMC12632412 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature