Targeting Radiation-Induced Glioma-Initiating Cells in Patient-Derived Glioblastoma.

ABSTRACT:

Background

Glioblastoma (GB) is a highly aggressive and treatment-resistant brain cancer with poor prognosis. Surgical resection followed by radiotherapy (RT) with the chemotherapeutic, temozolomide (TMZ), is the standard GB treatment; yet recurrence often occurs. GB is organized hierarchically with a small population of radiation-resistant glioma-initiating cells (GICs) that self-renew and drive tumor growth. Importantly, RT can induce a subset of cells from non-tumor-initiating into glioma-initiating cells (iGICs). Both GICs and iGICs contribute to tumor recurrence and therapy resistance. Thus, without effective elimination of non-tumorigenic GB and prevention or targeting of GICs, a cure is unlikely. The objective of this study is to identify small molecules that block RT-induce

SUBMITTER: Cardenas A 

PROVIDER: S-EPMC12632416 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature