Planarian behavioral screening is a useful invertebrate model for evaluating seizurogenic chemicals.

ABSTRACT: Detecting adverse health effects of drugs and other chemicals early during chemical/drug development saves significant time and resources. Freshwater planarians are an emerging invertebrate model for rapid, cost-effective neurotoxicity screening. Because planarians exhibit seizure-like behavior when exposed to chemicals that cause seizures in mammals, such as N-methyl-D-aspartate (NMDA) and picrotoxin, they could be a useful first-tier model for seizure screening and thus reduce the need for slow and expensive mammalian tests. However, planarian seizure studies to date have been low-throughput and lacking the necessary standardization and automation to make this model a viable screening solution. Here, we present results from medium-throughput behavioral testing conducted in 48-well plates

SUBMITTER: Ireland D 

PROVIDER: S-EPMC12632479 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature