Proteomic Characterization of Striatal Neurabin Interactome and its Sex Specific Impact on Motor Behavior.

ABSTRACT: The striatum serves as the primary input nucleus of the basal ganglia. Reversible protein phosphorylation in the post synaptic density (PSD) of medium spiny neurons (MSNs) modulates inputs from striatal afferents. The context dependent regulation of PSD protein phosphorylation in direct-pathway medium spiny neurons (dMSNs) and indirect-pathway medium spiny neurons (iMSNs) works to differentially and synergistically impact striatal physiology and the execution of motor programs. An important regulator of PSD protein phosphorylation is protein phosphatase 1 (PP1), which obtains substrate specificity through the action of PP1 targeting proteins. While prior work has demonstrated the global and cell type-specific impact of the PP1 targeting protein, spinophilin, on striatal motor behaviors lik

SUBMITTER: Shah NR 

PROVIDER: S-EPMC12632487 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature