Neuropathic pain drives time-dependent reorganization of corticostriatal circuits.

ABSTRACT: Chronic pain fundamentally alters sensorimotor integration and motivated behaviors, yet the neural mechanisms underlying this transition remain poorly understood. The striatum, composed of dopamine receptor type 1 (D1)- and type 2 (D2)- expressing spiny projection neurons (SPN), integrates cortical sensory and motor inputs to coordinate movement and motivation, making it a critical candidate for mediating pain-induced behavioral adaptations. Although spinal and cortical pain circuits are well-characterized in limited phases of pain, how corticostriatal pathways and distinct striatal cell populations contribute to the transition from acute to chronic pain states remains unclear. Here we show that neuropathic pain, after spared nerve injury in mice, produces temporally distinct, cell-type-sp

SUBMITTER: George AJ 

PROVIDER: S-EPMC12632498 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature