Recovering the pre-colonial population structure of Khoe-San descendant populations.

ABSTRACT: San populations from Botswana and Namibia retain exceptional linguistic, cultural and genetic diversity, but few Khoisan-speaking groups remain south of the Kalahari Desert. However, historically, far southern Africa was home to many San and Khoekhoe groups. Popular opinion often implies that such populations do not contribute to the ancestry of contemporary South Africans. Here, we characterize the genetic ancestry of self-identified South African Coloured groups and reconstruct pre- and colonial population structure from 620 newly sampled individuals. These groups retain majority Khoe-San genetic ancestry (>48%), suggesting the persistence of Khoe-San ancestry to the present day. By isolating the Khoe-San ancestry component, we show that it is intermediate between the ≠Khomani San and Na

SUBMITTER: Edington SL 

PROVIDER: S-EPMC12632568 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature