Synchronized path-integration recalibration but distinct landmark-control dynamics in head direction and CA1 place cells.

ABSTRACT: Accurate spatial navigation relies on path integration, a process of tracking one's location by integrating self-motion cues. Path integration uses a gain factor relating self-motion signals to displacement on the cognitive map. This gain is plastic, recalibrating rapidly to match perceived displacements relative to external cues. To elucidate the mechanism of recalibration, we simultaneously recorded from place cells, which instantiate the cognitive map, and head direction (HD) cells, thought to orient the map. Persistent conflict between self-motion and visual feedback induced functionally identical recalibration of path-integration gain in the two neural populations during forward locomotion; however, during locomotor immobility accompanied by head-scanning, HD cells did not exhibit rec

SUBMITTER: Jayakumar RP 

PROVIDER: S-EPMC12632603 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature