Blood transcriptomic signatures predict poor treatment outcomes in drug-susceptible pulmonary TB in Brazil.

ABSTRACT:

Background

Non-sputum biomarkers to monitor tuberculosis (TB) treatment and predict poor outcomes are lacking. We evaluated host-blood transcriptomic signatures for treatment monitoring and prognosis (death, treatment failure, recurrence) in adults with pulmonary TB.

Methods

Adults with culture-confirmed, drug-susceptible pulmonary TB were enrolled at five Brazilian sites. Whole-blood PAXgene samples were collected at baseline, month 2 (M2), and end of treatment (EoT). Treatment failure was defined as sputum culture positivity at month 5 or later. Participants were followed for 24 months from treatment initiation for clinical or microbiological TB recurrence. Unfavourable outcomes were matched ~1:3 to recurrence-free cure. Twenty-two published blood transcriptomic signatures

SUBMITTER: Mendelsohn SC 

PROVIDER: S-EPMC12632667 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature