Safety and potential benefits of acute intermittent hypoxia in people with chronic traumatic brain injury.

ABSTRACT:

Background

Acute intermittent hypoxia (AIH) was recently demonstrated to improve motor and cognitive function in several patient populations, including incomplete spinal cord injury, stroke, multiple sclerosis and mild cognitive impairment.

Objective

Our clinical trial aimed to establish if AIH can be safely administered in patients with traumatic brain injury (TBI) and to collect preliminary data about its potential efficacy for treating motor, cognitive and affective sequelae of TBI.

Methods

Twelve volunteers with chronic TBI underwent four AIH sessions conducted on separate days, in which they were exposed to fifteen 30-60-s hypoxic episodes interspersed with 60-90 s of breathing ambient air. Inspired oxygen (O₂) concentration during hypoxic episodes was

SUBMITTER: Delikishkina E 

PROVIDER: S-EPMC12632692 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature