Functional heterogeneity and plasticity in naive CD8 T cells drive superior effector and memory responses.

ABSTRACT: While significant progress has been made in defining subsets among antigen-experienced CD8 T cells, the heterogeneity of naïve CD8 T cells remains poorly understood. Here, we identify naïve CD8 T cell subsets with superior persistence and an enhanced capacity to generate effector and memory cells, leading to more effective protection. These high-quality naïve CD8 T cells are marked by IL-18Rα, CD73, and CXCR3, and functionally less potent naïve CD8 T cells can convert into these superior subsets. Their enhanced response to infections is driven by better survival of the progeny effector cells during the T cell expansion phase. This improved survival is mediated by increased Ly6C2 expression on effector cells derived from these high-quality naïve cells. Collectively, our findings reveal func

SUBMITTER: Sajiki Y 

PROVIDER: S-EPMC12632747 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature