HIV-associated non-Hodgkin lymphoma tumor-microenvironment axes differ by EBV status across cellular origins.

ABSTRACT: Non-Hodgkin Lymphoma (NHL) is the main cancer-related mortality for people living with HIV (PLWH). NHL genetic and molecular classifications have been intensely studied and correlated with clinical outcomes, but critical unanswered questions relevant to malignancy persist. For example, tumors positive for Epstein-Barr virus (EBV) are aggressive and account for 30-50% of HIV-associated NHLs, yet insights on the nature of EBV in NHL pathogenesis or potential therapeutic vulnerabilities have been limited. Here, we examined HIV-associated NHLs stratified by histopathologic classification, cell of origin (COO), molecular subtype, and EBV status using genome-wide spatial transcriptomic analyses. Tumor tissues in EBV⁺ HIV-NHLs displayed enriched expression of mitochondrial respiration

SUBMITTER: Chadburn A 

PROVIDER: S-EPMC12632762 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature