Hierarchical regulation of cerebellar neurogenesis by Sin3A-mediated gene repression.

ABSTRACT: Cerebellar granule cells (GCs) are critical for motor and cognitive functions. Lineage tracing studies have identified a hierarchical developmental progression of GC neurogenesis, transitioning from Sox2⁺ stem-like cells to Atoh1⁺ rapidly proliferating granule cell precursors (GCPs), and ultimately to NeuN⁺ mature GCs. However, the molecular mechanisms governing these transitions remain poorly understood. In this study, we identified a transient, slow-cycling progenitor population defined by co-expression of Sox2 and Atoh1. We show that GC maturation depends critically on the repressive function of the Sin3A/Hdac1 complex, which sequentially silences Sox2 and then Atoh1 to ensure orderly progression through developmental stages. Loss of these repressions pr

SUBMITTER: Chen L 

PROVIDER: S-EPMC12632768 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature