Depot-specific roles for sphingosine kinase 1 in conversion of white adipose to thermogenic adipose.

ABSTRACT:

Background

As of 2023, approximately 100.1 million adults and 14.7 million children in the USA are obese. Many comorbidities develop with obesity, which impairs quality of life and burdens the health care system. Consequently, there is an urgent need for interventions and treatments to reverse obesity and its comorbidities and restore health. Sphingosine Kinase 1 (SphK1), a key enzyme in sphingolipid metabolism, produces sphingosine-1-phosphate (S1P), a bioactive lipid implicated in obesity and metabolic dysfunction. While global deletion of Sphk1 protects against diet-induced obesity, adipocyte-specific SPHK1 deficiency paradoxically promotes weight gain, glucose intolerance, and adipose inflammation. Given the known role of sphingolipids in adipose thermogenesis, we invest

SUBMITTER: Valentine Y 

PROVIDER: S-EPMC12632792 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature