The impact of the serotonergic psychedelic DOI on active vision in freely moving mice.

ABSTRACT: Psychedelic compounds have the ability to generate altered states of consciousness and profoundly distort perception, often resulting in visual hallucinations. While psychedelics have recently regained attention for their potential cognitive and therapeutic effects, how these drugs affect visual processing to generate visual distortions and hallucinations is not as well characterized. Furthermore, studies investigating the effect of psychedelics on visual function have all been performed using head-fixed preparations, preventing animals from engaging in the natural visual behaviors that the visual system evolved to support. To determine the impact of psychedelics on active vision, we recorded neural activity in primary visual cortex (V1) of mice during free movement, while simultaneously r

SUBMITTER: Skyberg RJ 

PROVIDER: S-EPMC12632800 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature