Large-scale single-cell phylogenetic mapping of clonal evolution in the human aging esophagus.

ABSTRACT: The human somatic genome evolves throughout our lifespan, producing mosaic individuals comprising clones harboring different mutations across tissues. While clonal expansions in the hematopoietic system have been extensively characterized and reported to be nearly ubiquitous, clonal mosaicism (CM) has more recently also been described across multiple solid tissues. However, outstanding questions remain about the parameters and processes of human somatic evolution in non-cancerous solid human tissues, including when clones arise, how they evolve over time, and what mechanisms lead to their expansion. Questions of timing and clonal dynamics can be addressed through phylogenetic reconstruction, which serves as a 'temporal microscope', while uncovering the mechanisms of expansion necessitates

SUBMITTER: Prieto T 

PROVIDER: S-EPMC12632828 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature