Lectin Microarray-based Glycomics and Machine Learning Identify Shared Osteoarthritis Biomarkers in Humans, Dogs, and Horses.

ABSTRACT: Post-traumatic osteoarthritis (PTOA) is a common sequela to joint injury in both humans and companion animal species such as horses and dogs. Despite the increasing prevalence of osteoarthritis (OA) in humans, investigation of glycosylation changes associated with OA remains in its infancy. Recent advances, such as lectin microarray analysis, now enable detailed glycan profiling in complex biofluids such as synovial fluid. Using lectin microarray technology, this study characterized glycosylation patterns in synovial fluid samples from healthy and OA-affected joints in horses, dogs, and humans. Comparative glycan-binding profiles within and between species revealed conserved and distinct glycomic signatures associated with OA. Machine learning models, including classification algorithms, e

SUBMITTER: Peralta AG 

PROVIDER: S-EPMC12632833 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature