The mycomembrane proteins PorH and ProtX are inserted at polar growth zones and linked to the cell wall.

ABSTRACT: The Mycobacteriales order of bacteria includes important pathogens such as Mycobacterium tuberculosis. These organisms are surrounded by a unique cell envelope architecture that includes a two-layered cell wall composed of peptidoglycan (PG) and arabinogalactan. They also build an outer membrane called the mycomembrane that is made of mycolic acids. Mycolate outer membrane proteins (MOMPs) reside within the mycomembrane and a subset are thought to form pores that allow essential nutrients to permeate the envelope. However, little is known about the structure of these proteins or the mechanism by which they are assembled. Here, we investigate MOMP assembly in the model organism Corynebacterium glutamicum (Cglu) using PorH as a model MOMP. PorH is encoded in an operon wi

SUBMITTER: Hart EM 

PROVIDER: S-EPMC12632848 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature