Mismatch negativity develops in adolescence and independently of microglia.

ABSTRACT: Higher brain functions and cognition undergo a critical period of development during adolescence, when psychiatric disorders such as schizophrenia typically onset. Understanding how developmental processes during adolescence interact with schizophrenia pathophysiology and risk remains a central goal in psychiatry. Here we show that a well-established biomarker of schizophrenia, mismatch negativity, matures during adolescence in mouse primary visual cortex, along with a strengthening of fronto-visual functional connectivity. Because microglia are implicated in schizophrenia risk and disease states, we further investigated what role microglia may play in the development of mismatch responses under physiological conditions. We found that microglial depletion with PLX5622 in adolescence arrest

SUBMITTER: Rader Groves AM 

PROVIDER: S-EPMC12632862 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature