Primary metabolism determines the outcome of salicylic acid-mediated immune induction.

ABSTRACT: Controlling the deleterious effects of immune responses is as vital as fighting infection. In plants, this is achieved, in part, by circadian clock-mediated regulation, such as the synthesis of and response to the immune hormone salicylic acid (SA)^1,2. Application of SA at the same concentration under light/dark cycles induces immunity with minimal impact on growth, however, prolonged darkness leads to plant death². To uncover what determines this life-or-death outcome, we identified twenty survival of SA-induced death (ssd) mutants through genetic screening. These mutants are defective in starch, glucose, and nitrate metabolism, and circadian regulation, and accumulate excessive starch and/or glucose. Likewise, glucose application rescues SA-treated pla

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12632896 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature