Uncertainty Shapes Neural Dynamics in Motor Cortex During Reaching.

ABSTRACT: Voluntary reaching movements are often made with incomplete information about the movement goal, which may require the brain to flexibly adjust motor plans and ongoing movements. To examine how uncertainty about a reach target influences neural preparation and execution, we recorded activity from dorsal premotor (PMd) and primary motor (M1) cortices of a rhesus macaque trained to reach to one of two potential targets. In the task, a timing cue flashed three times in succession. Potential targets were displayed at the time of the first flash and the monkey needed to initiate the movement almost simultaneously with the third flash. Colorings of potential targets indicated the probability that the target would be at one location or the other, thereby inducing varying levels of uncertainty abo

SUBMITTER: Arakeri TJ 

PROVIDER: S-EPMC12632930 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature