CIViC MCP: Integrating Large Language Models with the Clinical Interpretations of Variants in Cancer.

ABSTRACT:

Summary

The Clinical Interpretation of Variants in Cancer (CIViC) knowledgebase provides a community-driven, open-source platform for discussing the biological and Clinical Significance of molecular variants in cancer. To enable users to make complex connections between CIViC information, we developed the CIViC Model Context Protocol (MCP) server, which allows large language models (LLMs) to directly interface with the CIViC API through natural language, facilitating the rapid summarization of expertly curated cancer variant interpretations.

Availability and implementation

The CIViC MCP server is detailed at https://github.com/griffithlab/civic-mcp-server with archived code and evaluation data deposited in Zenodo (DOI: 10.5281/zenodo.17344050). The repository is a fork of ht

SUBMITTER: Schimmelpfennig L 

PROVIDER: S-EPMC12632937 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature