Computational biophysical characterization of a superradiant virus-like particle in its ground state.

ABSTRACT: Superradiance (SR) arises when fluorophores radiate collectively rather than independently, producing ultrabright emission bursts. Recent experiments show that dye-labeled virus-like particles (VLPs) can exhibit SR at room temperature, where the VLP scaffold organizes dyes into a macrodipole of coherent emitters under pulsed excitation. To elucidate the biophysical basis of this phenomenon, microsecond-scale all-atom molecular dynamics (MD) simulations were performed on intact Brome mosaic virus (BMV) VLPs, comparing the native scaffold to a capsid decorated with Oregon Green 488 (OG). Results show that OG conjugation at K105 induces only subtle structural changes: a slight expansion of VLP volume and marginally higher inter-subunit flexibility, while overall shell morphology and pore arch

SUBMITTER: Krishna A 

PROVIDER: S-EPMC12632957 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature