Optimized reference region and the effect on test-retest reliability and detection of Parkinson's disease with [¹¹C]UCB-J.

ABSTRACT: [¹¹C]UCB-J is a radioligand targeting synaptic vesicle glycoprotein 2A, used to image synaptic density. For quantification, a small-volume centrum semiovale area was previously optimized as a [¹¹C]UCB-J reference region (CS2mL); however, its high variability resulted in reduced reliability. Herin, we evaluated an alternative reference region method to assess longitudinal test-retest reliability and detection of Parkinson's disease (PD). For estimating distribution volume ratio (DVR), CS2mL and eleven white matter (WM) reference regions (range: 0.5-200 mL) were generated using the Freesurfer WM map. Same-day and longitudinal test-retest variability (TRV) were assessed (24 healthy subjects (HS); n=10 same-day and n=20 longitudinal HRRT scans, range: 7-1028 days). Each r

SUBMITTER: Khattar N 

PROVIDER: S-EPMC12632983 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature