Cingulate-centered flexible control: physiologic correlates and enhancement by internal capsule stimulation.

ABSTRACT: The flexible deployment of cognitive control is essential for adaptive functioning in dynamic environments given limited cognitive resources. That flexibility depends on rapid detection and resolution of control-prediction errors (CPEs) when current demands diverge from the control plan. Deficits in control and control flexibility are common in psychiatric disorders, yet targeted interventions are limited by incomplete circuit-level understanding and limited means for modulating control circuits . We analyzed two intracranial electroencephalography datasets (one with brief internal capsule stimulation, ICS) to identify a human neurocomputational mechanism for CPE resolution and to test its modifiability. A third dataset of patients receiving internal capsule deep brain stimulation (IC DBS)

SUBMITTER: Kim J 

PROVIDER: S-EPMC12633030 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature