Melt Electrowritten Scaffold-Reinforced Affibody-Conjugated Hydrogels for Controlled Bone Morphogenetic Protein-2 Delivery.

ABSTRACT: Bone morphogenetic protein-2 (BMP-2) is clinically used to promote bone regeneration but suffers from uncontrolled release when delivered from collagen sponges, necessitating high doses that can cause adverse effects. Hydrogels offer tunable protein release but are limited by weak mechanics and poor stability during storage and handling. Here, we introduce a two-part protein delivery platform that integrates mechanical reinforcement with affinity-controlled protein release. We developed a melt electrowritten (MEW) scaffold-reinforced, affibody-conjugated polyethylene glycol maleimide (PEG-mal) hydrogel for affinity-controlled BMP-2 delivery. MEW scaffolds improved hydrogel handling, compressive resistance, and stability during lyophilization and rehydration, without altering bulk stiffness

SUBMITTER: Dorogin J 

PROVIDER: S-EPMC12633032 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature