Serum Metabolites Associated with Depression and Anxiety in the Hispanic Community Health Study/Study of Latinos.

ABSTRACT: Omics signatures for psychiatric conditions have been under-investigated. This study aimed to identify serum metabolites associated with symptoms of depression or anxiety in Hispanic/Latino adults and to develop and assess metabolite risk scores (MRSs) of these phenotypes. Using data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we conducted a metabolome-wide association study of 768 metabolites with depression and anxiety symptoms. We used two separate assay batches measured from baseline samples collected between June 2008 and July 2011 for discovery (batch 1: n=4,002 adults) and replication (batch 2: n=2,178 adults). We estimated the associations via survey-based generalized linear regression, and applied Least Absolute Shrinkage and Selection Operator (LASSO) re

SUBMITTER: Qiu X 

PROVIDER: S-EPMC12633118 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature