A bioluminescence-based chemical screen identifies a bactericidal naphthalene scaffold targeting MmpL3 in <i>Mycobacterium abscessus</i>.

ABSTRACT: Mycobacterium abscessus pulmonary disease (Mabs-PD) presents a significant and growing global health threat, particularly in individuals with underlying lung conditions like cystic fibrosis and chronic obstructive pulmonary disease. A key challenge in treating Mabs-PD is the lack of bactericidal antibiotics effective at therapeutically relevant concentrations, underscoring an urgent need for drug discovery. Targeting cell-wall synthesis is a promising approach, as evidenced by the success of broad-spectrum β-lactam antibiotics and the frontline antituberculosis drug isoniazid. However, these agents exhibit limited efficacy against Mabs, often requiring concentrations unachievable in lung tissues. Here, we used a bioluminescence-based whole-cell assay optimized to identify drugs targ

SUBMITTER: Singh S 

PROVIDER: S-EPMC12633243 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature