Aberrant E-I Balance and Brain Criticality in Major Depressive Disorder.

ABSTRACT: Brain criticality and complexity are increasingly recognized as promising biomarkers for psychiatric disorders. In Major Depressive Disorder (MDD), disordered neural dynamics have been reported, but their nature and consistency remain incompletely understood. Here, we study brain criticality, excitation-inhibition (E/I) balance, combined excitation-inhibition strength (E+I), and complexity of brain dynamics associated with MDD. Using resting-state EEG from 183 patients with MDD and 133 healthy controls (HC), we identified disruptions of critical dynamics and excitation-inhibition balance which discriminate groups. We found that amplitude bistability is lower, and long-range temporal correlations are weaker in MDD, implying deviation from criticality. Excitation-inhibition metrics show freq

SUBMITTER: Mitsuto A 

PROVIDER: S-EPMC12633248 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature