Multi-omic integration reveals dynamic changes in human placental metabolism across gestation.

ABSTRACT:

Objectives

Metabolic demands of the developing conceptus are highly dynamic during pregnancy. While placental metabolism has been well described at term and in cell lines, changes in the placental metabolome during development remains understudied. We investigated the placental metabolome, metabolite trajectories, and altered pathways across trimesters in normal human pregnancy by integrating metabolomic and transcriptomic data.

Methods

Targeted aqueous metabolomic profiling of 372 metabolites was conducted on placental biopsies from samples collected in the first (n=12), second (n=13), and third (n=11) trimesters of normal pregnancy using liquid chromatography-tandem mass spectrometry. Robust linear models identified differentially abundant metabolites

SUBMITTER: Parenti M 

PROVIDER: S-EPMC12633274 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature