Variation of Myelin-associated Gene Expression and <i>Ndrg1</i> within the Prefrontal Cortex as Determinants for Initial Level of Response to Alcohol.

ABSTRACT:

Background

Studies in humans and animal models have documented relationships between initial sensitivity to alcohol and alcohol drinking behavior.Prior expression profiling studies of C57BL/6J and DBA/2J mice and rhesus macaques within the prefrontal cortex (PFC) have shown variation in myelin gene expression may be linked with alcohol sensitivity and consumption.

Methods

Combining gene expression studies from human and mouse PFC, we identified a cross-species gene network enriched for myelin-associated genes. Since myelin expression is correlated to alcohol sensitivity and alcohol drinking behavior, we hypothesized basal levels of PFC myelin gene expression may be a genomic determinant for these behavioral responses. Using an animal model of CNS demyelination, and localized

SUBMITTER: Wolstenholme JT 

PROVIDER: S-EPMC12633287 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature