Modeling σ E biochemical network reveals context-dependent feedback control and kinetic constraints in the envelope stress response.

ABSTRACT: The bacterial cell envelope is essential for mechanical stability, barrier function, defining cell size and shape, and supporting cellular processes. Because external or internal stressors can challenge its integrity, bacteria have evolved stress response systems to maintain envelope homeostasis. For example, under stress, E. coli activates σE to induce a regulon that restores envelope homeostasis. The molecular mechanisms underlying the transcriptional and post-translational regulation of σE and its anti-sigma factor RseA have been well-mapped. However, how these regulatory layers function at the systems level to regulate σE activity remains unclear. Here, we combine mathematical modeling with quantitative gene expression measurements to determine how the interplay of transcription

SUBMITTER: Palma CSD 

PROVIDER: S-EPMC12633294 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature