Neuronal architecture of the mouse insular cortex underlying its diverse functions.

ABSTRACT: The insular cortex integrates interoceptive and exteroceptive information to mediate bodily homeostasis, emotion, learning, and potentially consciousness.^1-4 However, the cellular and circuit substrates governing the insula and other associative cortices are poorly understood compared to primary cortices. Here, we quantify the dendritic morphology together with electrical properties, local inputs, and/or projections of 1,093 insular pyramidal neurons. These neurons are mapped onto a quantitative anatomical model of the insula based on a Nissl-staining coordinate framework. Using improved algorithms, we define 21 morphological, 12 electrical, and 9 input neuronal types, and identify several morphological and input types that are unique to the insula. Further, we find that morphol

SUBMITTER: Jongbloets BC 

PROVIDER: S-EPMC12633321 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature