Regulatory T cells inhibit CD8⁺ T_RM-like cells during the early stages of tumor immune escape.

ABSTRACT: Tissue-resident memory T (T_RM) cells are increasingly recognized as crucial components of tumor immunosurveillance and potential targets in cancer immunotherapy. However, studying T_RM cells within the tumor microenvironment (TME) has been challenging due to limitations in existing tumor models. Traditional cell lines injected subcutaneously fail to replicate the biological cues of dermal and epidermal tumors, and many genetically engineered mouse models (GEMMs) lack a specific tumor antigen for tracking immune responses. Here, we use an autochthonous Braf/PTEN model of melanoma, modified to express OVA as a tumor-specific model antigen, to show that CD103⁺ T_RM-like cells orchestrate the initial antitumor immune response and this response is antag

SUBMITTER: Williams JB 

PROVIDER: S-EPMC12633329 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature