Ventral striatal astrocytes contribute to reinforcement learning.

ABSTRACT: Astrocytes influence synaptic plasticity and neuronal function through astrocytic calcium dynamics (ACD). However, astrocytes' contribution to cognitive operations like reinforcement learning (RL) remains unclear. To examine this, we trained mice on a RL dependent probabilistic decision-making task. We attenuated ACD across distinct striatal regions, finding that ACD attenuation specifically in ventral striatum (VS) increased decision noisiness and impaired reward-guided choice. This effect was largely due to a reduction in "win-stay" behavior. Using in-vivo calcium imaging, we found that VS ACD correlated with reward prediction errors (RPEs). Furthermore, these trial-by-trial ACD fluctuations predicted trial-by-trial choice variability. Finally, ex-vivo slice electrophysiology and computa

SUBMITTER: Pai J 

PROVIDER: S-EPMC12633354 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature