Disentangling structure-function relationships between the human hippocampus and the whole brain using track-weighted dynamic functional connectivity.

ABSTRACT: Understanding how structural and functional connectivity shape hippocampal interactions with the rest of the brain is critical for elucidating its role in cognition. Here, we combine high-resolution diffusion MRI, a novel fibre-tracking pipeline designed to specifically probe anatomical connectivity of the in vivo human hippocampus, and track-weighted dynamic functional connectivity (TW-dFC) to investigate how direct anatomical connections between the hippocampus and the rest of the brain relate to time-varying functional interactions. In Study 1, TW-dFC maps were computed for 10 participants from the Human Connectome Project and subjected to ICA and k-means clustering to derive a data-driven parcellation of the hippocampus based on its structure-function relationships. This reveale

SUBMITTER: Dalton MA 

PROVIDER: S-EPMC12633360 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature