Mechanical control of histone serotonylation initiates neural crest migration <i>in vivo</i>.

ABSTRACT: Collective cell migration (CCM) is pivotal in several biological contexts, and posttranslational modifications of histones are essential to initiate this process^1-3. Here, we show that a recently discovered chromatin mark, termed histone serotonylation⁴, is involved in the collective migration of cranial neural crest cells - an embryonic multipotent stem cell population⁵. Our in vivo data reveal that histone serotonylation appears in neural crest cells just before they start migrating and that its occurrence is essential to initiate their CCM. Surprisingly, we found that stiffening of the neural crest migratory substrate, the mesoderm, induces histone serotonylation by promoting nuclear translocation of transglutaminase 2 (Tgm2), the enzyme responsib

SUBMITTER: Saraiva JE 

PROVIDER: S-EPMC12633372 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature