Long-term temporal stability of circulating proteins in older adults.

ABSTRACT: Circulating proteins reflect diverse biological processes and can offer critical insights into an individual's overall health and aging trajectory. The circulating proteome is shaped by a complex interplay of genetic, biological, and environmental factors across the lifespan. However, little is known about which factors influence its long-term temporal stability. Here we used SomaScan proteomics to evaluate the five-year temporal stability of 7,288 proteins measured in serum from 3,093 participants (mean age 76 years) of the Age, Gene/Environment Susceptibility (AGES)-Reykjavik study. We observed a wide variability in the temporal stability of individual proteins, with temporally stable proteins more often being extracellular and associated with diseases, while temporally variable proteins

SUBMITTER: Ingvarsdottir HK 

PROVIDER: S-EPMC12633528 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature