Symptoms of problematic alcohol use differ in their genetic associations with comorbid internalizing, externalizing, and neurodevelopmental psychiatric disorders.

ABSTRACT:

Background and aims

Certain symptoms of problematic alcohol use (PAU) show associations with comorbid internalizing and externalizing disorders even after controlling for their common PAU factor. Outsized associations between PAU indicators and comorbid psychopathology may reflect distinct etiologic pathways or measurement characteristics that, if unaccounted for, could bias comorbidity estimates with PAU. Although these issues could represent a source of bias in estimates of genetic correlation with PAU, no studies have yet extended this work using genomic data.

Design

Genomic structural equation modeling and the Qtrait function identified PAU indicators that showed appreciable residual genetic correlations with eleven comorbid psychiatric disorders and whose associations d

SUBMITTER: Wang FL 

PROVIDER: S-EPMC12633565 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature