Affective Neuropsychiatric Symptom Metrics in the National Alzheimer's Coordinating Center Dataset.

ABSTRACT:

Background

In dementia research, affective neuropsychiatric symptoms (NPS) - depression, anxiety, and apathy - remain understudied. Improving strategies to accurately identify clinically relevant NPS is essential for more robust research.

Objectives

We sought to determine how often objective metrics and clinical gestalt metrics agree on NPS presence or absence. We further sought to determine optimal cut-offs for affective NPS presence/absence using the Neuropsychiatric Inventory Questionnaire (NPI-Q) severity ratings.

Methods

We assessed agreement for NPS presence/absence among 5 different depression metrics, 4 anxiety metrics, and 2 apathy metrics via Jaccard indices using the National Alzheimer's Coordinating Centers (NACC) dataset. Analysis included exploring diffe

SUBMITTER: Fisher DW 

PROVIDER: S-EPMC12633568 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature