Novel integrase mutations linked to genotypic DTG resistance in non-B HIV-1 strains from African participants: The DTG RESIST study.

ABSTRACT:

Background

Integrase mutations associated with dolutegravir resistance have been well characterized, but based on limited data from non-B subtypes.

Objectives

We aim to identify integrase mutations not currently classified as integrase strand transfer inhibitor (INSTI) resistance mutations (DRMs) in individuals with viremia on dolutegravir-based regimens.

Methods

Mutations in integrase sequences in the DTG RESIST study from African countries were detected using Stanford HIVdb v9.8. We used a viral genome-wide association study (GWAS) approach to identify mutations not classified as major or accessory INSTI DRMs but associated with dolutegravir resistance. We performed the same GWAS on drug-naïve sequences from the Los Alamos HIV-1 database to identify mutations associ

SUBMITTER: Han N 

PROVIDER: S-EPMC12633578 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature