Recurrent <i>Plasmodium falciparum</i> parasitemia and drug resistance mutations during intermittent preventive treatment of malaria in pregnancy in Uganda.

ABSTRACT:

Background

Intermittent preventive treatment with monthly sulfadoxine-pyrimethamine (IPTp-SP) is recommended during pregnancy in malaria-endemic countries. However, widespread resistance of Plasmodium falciparum to SP has compromised its efficacy, and the alternative dihydroartemisinin-piperaquine (DP) is under study. Potential selection of drug resistance is of interest.

Methods

We sequenced 1377 samples collected from pregnant women enrolled in a trial comparing monthly SP, DP, and DP+SP for IPTp in Busia, Uganda and with asymptomatic parasitemia at the time of IPTp administration. We characterized known markers of drug resistance and assessed the 28-day cumulative risk of recurrent parasitemia, with genotyping to distinguish recrudescence from new infections.

Re

SUBMITTER: Kizza J 

PROVIDER: S-EPMC12633580 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature