Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood.

ABSTRACT: Clonal hematopoiesis, through the age-associated accumulation of somatic mutations in blood, is strongly associated with hematological malignancies and other chronic diseases. These mutations have largely been characterized in individuals of European ancestry or environments, and consequently, it remains unclear how mutation-recurrence patterns vary across populations of different histories or non-European ancestries. Here, we evaluate how variation in geography, ancestry, genetics and sex shape the prevalence of mosaic chromosomal alterations (mCAs) among 47,369 individuals from the Canadian Partnership for Tomorrow's Health, including a founding population cohort in Quebec, and 13,562 individuals from within South, Central, West and East Africa though the H3Africa consortium. We identifi

SUBMITTER: Won Kang JR 

PROVIDER: S-EPMC12633608 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature